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پروتئین هترولوگ
Of these, episomal plas mid vectors have been used extensively for the production of either intra or extracellular heterologous proteins.
Secretion of Heterologous Proteins by S. cerevisiae
Overexpression of the molecular chaperone BiP or protein disulfide iso merase increased the secretion of some heterologous protein; however, overexpression of a single chaperone may not have the desired outcome and, in some instances, may increase the degradation of the target protein.
The outcome is the production of a sialylated protein in humans and a hy permannosylated protein in yeast, with a1,3 bonds between the sugar resi dues that can make the heterologous protein antigenic in humans (Fig. 3.24).
Authentic heterologous proteins for industrial and pharmaceutical uses have also been generated in other yeasts.
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